Updated with news of the death.
The Boston Fire Department responded at 8:39 a.m. to 94 George St. in Roxbury for what turned into a three-alarm blaze.
Firefighters found one dead person at the scene; the exact cause to be determined in an autopsy. A second person was taken to the hospital with serious burns.
The house collapsed - after firefighters were ordered to stay at least 50 feet away.